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SATB2 Antibody

Rabbit Monoclonal IgG

  • WB - SATB2 Antibody AJ1706a
    Western blot analysis on (A) HT-1080, (B) SW1353, and (C) MCF-7 cell lysates using anti-SATB2 RabMAb (Cat. #AJ1706a).
  • IHC - SATB2 Antibody AJ1706a
    Immunohistochemical analysis of paraffin-embedded human fetal brain tissue using anti-SATB2 RabMAb (Cat. #AJ1706a).
  • IF - SATB2 Antibody AJ1706a
    Immunofluorescent staining of SHSY5Y cells using anti-SATB2 RabMAb (Cat. #AJ1706a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UPW6
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPNCIR130A
Calculated MW 82555 Da
Gene ID 23314
Other Names DNA-binding protein SATB2, Special AT-rich sequence-binding protein 2, SATB2, KIAA1034
Target/Specificity A synthetic peptide corresponding to residues in human SATB2 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSATB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SATB2
Synonyms KIAA1034
Function Binds to DNA, at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcription factor controlling nuclear gene expression, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Required for the initiation of the upper- layer neurons (UL1) specific genetic program and for the inactivation of deep-layer neurons (DL) and UL2 specific genes, probably by modulating BCL11B expression. Repressor of Ctip2 and regulatory determinant of corticocortical connections in the developing cerebral cortex. May play an important role in palate formation. Acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation.
Cellular Location Nucleus matrix {ECO:0000255|PROSITE- ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00374, ECO:0000269|PubMed:14701874}
Tissue Location High expression in adult brain, moderate expression in fetal brain, and weak expression in adult liver, kidney, and spinal cord and in select brain regions, including amygdala, corpus callosum, caudate nucleus, and hippocampus
Research Areas
Citations (0)

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Special AT-rich sequence-binding protein 2 (SATB2) is a DNA-binding protein of the CUT homeobox family that regulates chromatin organization and gene expression (1). It functions as a transcription factor that controls nuclear gene expression. SATB2 binds to matrix attachment regions (MARs) of DNA, inducing local chromatin-loop remodeling (2). This protein acts as a docking site for several chromatin remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers (2). Furthermore, it acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation (3). It is highly expressed in the adult brain, with moderate expression in the fetal brain (2). In developing brains, SATB2 is expressed in cortical neurons that extend axons across the corpus callosum (1). Defects in SATB2 are the cause of isolated cleft palate with mental retardation (1).


1. Alcamo et al. Neuron. 57(3):364-77, 2008. 2. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 37:D169-D174 (2009). 3. Dobreva et al. Cell. 125(5):971-86, 2006.

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Cat# AJ1706a
(40 western blots)
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