|Application ||WB, IHC|
|Calculated MW||87387 Da|
|Other Names||Scavenger receptor class F member 1, Acetyl LDL receptor, Scavenger receptor expressed by endothelial cells 1, SREC-I, SCARF1, KIAA0149, SREC|
|Target/Specificity||A synthetic peptide corresponding to residues in human SCARF1 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SCARF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Endothelial cells.|
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Provided below are standard protocols that you may find useful for product applications.
Scavenger receptor class F member 1 (SCARF1) mediates the selective uptake of modified low density lipoprotein (LDL), such as acetylated LDL and oxidized LDL, into endothelial cells (1). It also mediates heterophilic interactions, suggesting that it functions as an adhesion protein (2). SCARF1 has several characteristic domain structures; an N-terminal extracellular domain with seven epidermal growth factor (EGF)-like cysteine pattern signatures, and an unusually long C-terminal cytoplasmic domain composed of a Ser/Pro-rich region followed by a Gly-rich region. SCARF1 is expressed at high levels in endothelial cells but not in smooth muscle cells (1).
1. Hideki Adachi, et al. The Journal of Biological Chemistry, 277:24014-24021, 2002 2. The UniProt Consortium. The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2008)
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