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SCF Antibody

Rabbit Monoclonal Antibody

  • WB - SCF Antibody AJ1708a
    A. Western blot analysis on 5ng of recombinant protein using SCF RabMAb (Cat. #AJ1708a), dilution 1:10,000.
  • IHC - SCF Antibody AJ1708a
    B. Immunohistochemical analysis of paraffin-embedded human kidney carcinoma using anti-SCF RabMAb (Cat. #AJ1708a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P21583
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP665Y
Calculated MW 30899 Da
Gene ID 4254
Other Names Kit ligand, Mast cell growth factor, MGF, Stem cell factor, SCF, c-Kit ligand, Soluble KIT ligand, sKITLG, KITLG, MGF, SCF
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human SCF was used as an immunogen.
Dilution WB~~1:50000~200000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSCF Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MGF, SCF
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein Soluble KIT ligand: Secreted.
Research Areas
Citations (0)

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Novel hematopoietic growth factor, stem cell factor (SCF), was cloned and demonstrated to be the ligand for the c-kit tyrosine kinase receptor. SCF is encoded by Sl (steel), a gene critical to the development of several distinct cell lineages during embryonic life and which has important effects on hematopoiesis in the adult (1). SCF is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow cultures. SCF exhibits potent synergistic activities in conjunction with colony-stimulating factors, resulting in increased colony numbers and colony size (2).


1. Geissler EN, et al. Somat Cell Mol Genet 17(2):207-14, 1991
2. Martin FH, et al. Cell 63(1):203-11, 1990

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Cat# AJ1708a
(40 western blots)
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