|Application ||WB, IHC|
|Calculated MW||25387 Da|
|Other Names||Serum amyloid P-component, SAP, 95S alpha-1-glycoprotein, Serum amyloid P-component(1-203), APCS, PTX2|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-term of human SAP was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Serum amyloid Antibodies P-Component (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.|
|Tissue Location||Found in serum and urine.|
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Provided below are standard protocols that you may find useful for product applications.
Serum Amyloid P (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits and this is probably due to its specific calcium-dependent binding to motifs present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits (1,2). It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T lymphocytes or B lymphocytes (3). SAP production can be induced by exposure to IL-1, IL-6 and IFN-beta. The SAP-inducing activity was neutralized by antibodies to each of the recombinant cytokines (4).
1. Togashi S, et al. Lab Invest 77(5):525-31, 1997
2. Bujl M, et al. Arthritis Rheum 48(1):248-54, 2003
3. MacDonald SL, Scand J Immunol 64(1):48-52, 2006
4. Lin BF, et al. Inflammation 14(3): 297-313, 1990
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