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SHIP Antibody

Rabbit Monoclonal Antibody

  • WB - SHIP Antibody AJ1714a
    A. Western blot analysis on Daudi cell lysate using anti-SHIP RabMAb (Cat. #AJ1714a), dilution 1:50,000
  • IHC - SHIP Antibody AJ1714a
    B. Immunohistochemical staining of paraffin-embedded human spleen using anti-SHIP RabMAb (Cat. #AJ1714a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00145
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP378Y
Other Names INPP5D, SHIP, SHIP1, Phosphatidylinositol-3, 4, 5-trisphosphate 5-phosphatase 1, p150Ship
Target/Specificity A synthetic peptide peptide corresponding to residues near the C-terminus of human SHIP was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSHIP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Citations (0)

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SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP1 to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2).


1. Tridandapani S, et al. Mol Cell Biol 17(8):4305-11
2. Malbec O, et al. J Biol Chem 276(32):30381-91

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Cat# AJ1714a
(40 western blots)

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