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SHIP Antibody Phospho (pY1020)

Rabbit Monoclonal Antibody

     
  • WB - SHIP Antibody Phospho (pY1020) AJ1714b
    Western blot analysis on Raji cell lysates using anti-Phospho-SHIP (pY1020) RabMAb (Cat. #AJ1714b). Cells were either (A) untreated (B) treated with Pervanadate.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O00145
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR425
Target/Specificity A synthetic peptide corresponding to residues surrounding Tyrosine 1020 of human SHIP was used as an immunogen.
Dilution WB~~1:2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSHIP Antibody Phospho (pY1020) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Research Areas
Citations (0)

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Background

SH2-containing inositol phosphatase 1 (SHIP) is a 145 kDa hemopoietic-specific phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP has been shown to bind directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of FcgammaRIIB1 (1). Also, results demonstrate that FcgammaRIIB use SHIP to inhibit pathways shared by receptor tyrosine kinases and immunoreceptors to trigger cell proliferation and cell activation, respectively (2). Phosphorylation on tyrosine 917 and tyrosine 1020 sites in SHIP have been shown to control migration by binding to DOK1, a regulating protein linked to the regulation of migration (3).

References

1. Tridandapani S, et al. Mol Cell Biol 17(8):4305-11 2. Malbec O, et al. J Biol Chem 276(32):30381-91 3. Sattler M., et al. J Biol Chem. 276(4):2451-8, 2001

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Discontinued
Cat# AJ1714b
Size:

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