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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   Phospho Antibodies   >   SLP-76 Antibody Phospho (pY113)   

SLP-76 Antibody Phospho (pY113)

Rabbit Monoclonal Antibody

  • WB - SLP-76 Antibody Phospho (pY113) AJ1720a
    A. Western blot analysis on Jurkat cell lysates using anti-Phospho-SLP-76 (pY113) RabMAb (Cat. #AJ1720a), 1:10,000 dilution. Cells were either (A) untreated (B) treated with pervanadate.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13094
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2851
Calculated MW 60188 Da
Gene ID 3937
Other Names Lymphocyte cytosolic protein 2, SH2 domain-containing leukocyte protein of 76 kDa, SLP-76 tyrosine phosphoprotein, SLP76, LCP2
Target/Specificity A phospho specific peptide corresponding to residues surrounding tyrosine 113 of human SLP-76. This antibody detects SLP-76 phosporylated on tyr113.
Dilution WB~~1:5000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLP-76 Antibody Phospho (pY113) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name LCP2
Function Involved in T-cell antigen receptor mediated signaling.
Cellular Location Cytoplasm.
Tissue Location Highly expressed in spleen, thymus and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines Not detected in fibroblast or neuroblastoma cell lines
Research Areas
Citations (0)

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The activation of protein tyrosine kinases is a critical event in T cell antigen receptor (TCR)-mediated signaling. One substrate of the TCR-activated protein tyrosine kinase pathway is a 76-kDa protein (SLP-76) that associates with the adaptor protein Grb2. Northern analysis demonstrates that pp76 mRNA is expressed solely in peripheral blood leukocytes, thymus, and spleen; and in human T cell, B cell and monocytic cell lines. In vitro translation of pp76 cDNA gives rise to a single product of 76 kDa that associates with a GST/Grb2 fusion protein, demonstrating a direct association between these two molecules. Results demonstrate that this novel protein is likely to play an important role in TCR-mediated intracellular signal transduction (1). It has been shown that both SLP-76 and ZAP70 co-immunoprecipitate with Shb in Jurkat T cells and that Shb and Vav co-immunoprecipitate when cotransfected in COS cells. Results indicate that upon TCR stimulation, Shb is targeted to these lipid rafts where Shb aids in recruiting the SLP-76-Gads-Vav complex to the T cell receptor zeta-chain and ZAP70 (2). Tyrosine phosphorylation of SLP-76 at position 113 or 128 was sufficient for it to associate with the N-terminal SH2 of p85. This data suggest that SLP-76 may play a role in PI3K signaling pathways (3).


1. Jackman JK, et al J Biol Chem 270(13):7029-32, 1995
2. Lindholm CK et al. Eur J Biochem 269(13):3279-88, 2002
3. Shim EK, et al. FEBS Lett 575(1-3):35-40, 2004

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Cat# AJ1720a
(40 western blots)
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