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SOD1 Antibody

Rabbit Monoclonal Antibody

  • WB - SOD1 Antibody AJ1729c
    A.Western blot analysis on (A) HeLa, (B) MCF-7, (C) Jurkat and (D) HT-29 cell lysates using anti-SOD1 RabMAb (Cat. #AJ1729c), dilution 1:200,000.
  • IHC - SOD1 Antibody AJ1729c
    B. Immunohistochemical analysis of paraffin-embedded human kidneys using anti-SOD1 RabMAb (Cat. #AJ1729c).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00441
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR1726
Calculated MW 15936 Da
Gene ID 6647
Other Names Superoxide dismutase [Cu-Zn], Superoxide dismutase 1, hSod1, SOD1
Target/Specificity A synthetic peptide corresponding to residues in human SOD1 was used as an immunogen.
Dilution WB~~1:100000~500000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOD1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOD1
Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria
Research Areas
Citations (0)

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Cu/Zn superoxide dismutase (SOD1), a major intracellular antioxidant enzyme, metabolizes superoxide radicals to molecular oxygen and hydrogen peroxide (1). SOD1 is primarily a cytosolic protein, and is ubiquitously expressed in many tissues at higher levels than in the brain and spinal cord (1, 2). The structural interplay of the conserved disulfide bond and metal-site occupancy in SOD1 is of increasing interest as these post-translational modifications are known to dramatically alter the catalytic chemistry, the subcellular localization, and the susceptibility of the protein to aggregation (3). Defective SOD is linked to motor neuron death and carries implications for understanding and possible treatment of the fatal neurodegenerative disorder familial amyotrophic lateral sclerosis (FALS) (4).


1. Jun-ichi Niwa, et al. J. Biol. Chem., 282(38):28087-28095, 2007
2. P. Andreas Jonsson, et al. Brain 129: 451-464, 2006
3. Arnesano F, et al. J Biol Chem 279(46):47998-8003, 2004
4. Deng HX, et al. Science 261(5124):1047-51, 1993

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Cat# AJ1729c
(40 western blots)
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