|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||24722 Da|
|Other Names||Superoxide dismutase [Mn], mitochondrial, SOD2|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-terminus of human SOD2 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SOD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|
|Cellular Location||Mitochondrion matrix.|
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Provided below are standard protocols that you may find useful for product applications.
Superoxide dismutase comprises a family of metalloenzymes that catalyze the oxido-reduction of superoxide anion to H2O2. Manganese superoxide dismutase (SOD2) is encoded by nuclear chromatin, synthesized in the cytosol, and imported posttranslationally into the mitochondrial matrix (1). It has been shown that SOD2 activity in tumor cells is lower than that in their normal counterparts. results suggest that the reduced level of SOD2 activity observed in human tumor cells is not due to a defect in the primary structure of the SOD2 protein, a change in the dosage of the SOD2 gene, or a decrease in the stability of SOD2 mRNA in tumor cells but rather is due to a defect or defects in the expression of the gene (2). SOD2 is one of the major cellular defense enzymes that protects against toxic effects of superoxide radicals. Overexpression of human SOD2 has been shown to inhibit radiation-induced neoplastic transformation, suppress malignancy of cancer cells, and increase tolerance to various toxic agents (3).
1. Wispe JR, et al. Biochim Biophys Acta 994(1):30-6, 1989
2. St. Clair DK et al. Cancer Res 51(3):939-43, 1991
3. Wan XS, et al. DNA Cell Biol 13(11):1127-36
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