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SOD2 Antibody

Rabbit Monoclonal Antibody

  • WB - SOD2 Antibody AJ1730a
    A. Western blot analysis on (A) rat brain lysate using anti-SOD2 RabMAb, dilution 1:2000. (B)SH-SY5Y lysate using anti-SOD2 RabMAb (Cat. #AJ1730a), dilution 1:500.
  • IHC - SOD2 Antibody AJ1730a
    B. Immunohistochemical analysis of paraffin-embedded human liver using anti-SOD2 RabMAb (Cat. #AJ1730a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04179
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR2560Y
Calculated MW 24722 Da
Gene ID 6648
Other Names Superoxide dismutase [Mn], mitochondrial, SOD2
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human SOD2 was used as an immunogen.
Dilution WB~~1:1000~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSOD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SOD2
Function Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Cellular Location Mitochondrion matrix.
Research Areas
Citations (0)

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Superoxide dismutase comprises a family of metalloenzymes that catalyze the oxido-reduction of superoxide anion to H2O2. Manganese superoxide dismutase (SOD2) is encoded by nuclear chromatin, synthesized in the cytosol, and imported posttranslationally into the mitochondrial matrix (1). It has been shown that SOD2 activity in tumor cells is lower than that in their normal counterparts. results suggest that the reduced level of SOD2 activity observed in human tumor cells is not due to a defect in the primary structure of the SOD2 protein, a change in the dosage of the SOD2 gene, or a decrease in the stability of SOD2 mRNA in tumor cells but rather is due to a defect or defects in the expression of the gene (2). SOD2 is one of the major cellular defense enzymes that protects against toxic effects of superoxide radicals. Overexpression of human SOD2 has been shown to inhibit radiation-induced neoplastic transformation, suppress malignancy of cancer cells, and increase tolerance to various toxic agents (3).


1. Wispe JR, et al. Biochim Biophys Acta 994(1):30-6, 1989
2. St. Clair DK et al. Cancer Res 51(3):939-43, 1991
3. Wan XS, et al. DNA Cell Biol 13(11):1127-36

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Cat# AJ1730a
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