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Stat-2 AntibodyRabbit Monoclonal Antibody
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AJ1738b | 100ul 400 ul | 2-3 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
Stat-2 Antibody - Product info | |
| Application | WB
|
| Primary Accession | Q9WVL2 |
| Reactivity | Mouse |
| Clone Names | EP1814Y |
| Calculated MW | 105417 Da |
| Target/Specificity A synthetic peptide corresponding to residues near C-terminus of mouse Stat-2 was used as immunogen. | |
| Dilution WB~~1:1000~2000 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Stat-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
Stat-2 Antibody - Protein Information | |
| Name Stat2 | |
| Function Transcription factor that binds to the IFN-stimulated response element (ISRE) and to the GAS element. This multiprotein transcription factor is termed ISGF3 | |
| Cellular Location Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus upon activation by IFN-alpha/beta (By similarity) | |
| Tissue Location Found in the brain, lung, heart, spleen, liver, kidney, muscle and the testis | |
Stat-2 Antibody - Related products
Stat-2 Antibody - Application data
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A.Western blot analysis on NIH 3T3 cell lysate using anti-Stat-2 RabMAb (Cat. #AJ1738b), dilution 1:2000.
Stat-2 Antibody - Research Areas
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Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Stat-2 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleus. Stat-2 is one of seven members of the Signal transducer and activators of transcription (Stats) family. Stat-2 is phosphorylated at Tyr690 by JAKs (1-3). Additionally, upon activation, Stat-2 will form a multi-protein DNA-binding complex with Stat-1 and ISGF3γp48 (4). This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements.
REFERENCES
1. Silvennoinen, O., Ihle, J. N., Schlessinger, J., and Levy, D. E. (1993) Nature 366, 583-585
2. Darnell, J. E., Jr. (1997) Science 277, 1630-1635
3. Fu, X.-Y., Kessler, D. S., Veals, S. A., Levy, D. E., and Darnell, J. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 8555-8559
4. Veals, S. A., Schindler, C., Leonard, D., Fu, X. Y., Aebersold, R., Darnell, J. E., and Levy, D. E. (1992) Mol. Cell. Biol. 12, 3315-3324
