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Stat-2 Antibody

Rabbit Monoclonal Antibody

  • WB - Stat-2 Antibody AJ1738b
    A.Western blot analysis on NIH 3T3 cell lysate using anti-Stat-2 RabMAb (Cat. #AJ1738b), dilution 1:2000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9WVL2
Reactivity Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP1814Y
Calculated MW 105417 Da
Other Names Signal transducer and activator of transcription 2, Stat2
Target/Specificity A synthetic peptide corresponding to residues near C-terminus of mouse Stat-2 was used as immunogen.
Dilution WB~~1:1000~2000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsStat-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Stat2
Function Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Cellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
Tissue Location Found in the brain, lung, heart, spleen, liver, kidney, muscle and the testis
Research Areas
Citations (0)

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Stat-2 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleus. Stat-2 is one of seven members of the Signal transducer and activators of transcription (Stats) family. Stat-2 is phosphorylated at Tyr690 by JAKs (1-3). Additionally, upon activation, Stat-2 will form a multi-protein DNA-binding complex with Stat-1 and ISGF3γp48 (4). This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements.


1. Silvennoinen, O., Ihle, J. N., Schlessinger, J., and Levy, D. E. (1993) Nature 366, 583-585
2. Darnell, J. E., Jr. (1997) Science 277, 1630-1635
3. Fu, X.-Y., Kessler, D. S., Veals, S. A., Levy, D. E., and Darnell, J. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 8555-8559
4. Veals, S. A., Schindler, C., Leonard, D., Fu, X. Y., Aebersold, R., Darnell, J. E., and Levy, D. E. (1992) Mol. Cell. Biol. 12, 3315-3324

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Cat# AJ1738b
(40 western blots)
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