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Stat-3 Antibody Phospho (pY705)

Rabbit Monoclonal Antibody

  • WB - Stat-3 Antibody Phospho (pY705) AJ1739d
    A. Western blot analysis on HeLa cell lysates using anti-Phospho-Stat3 (pY705) RabMAb (Cat. #AJ1739d), 1:20,000 dilution. Cells were either (A) untreated (B) treated with IFN-alpha.
  • IHC - Stat-3 Antibody Phospho (pY705) AJ1739d
    B. Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using anti-Phospho STAT3 (pY705) RabMAb (Cat. #AJ1739d).
  • IF - Stat-3 Antibody Phospho (pY705) AJ1739d
    C. Immunofluorescent staining of HeLa cells using anti-Phospho STAT3 (pY705) RabMAb (Cat. #AJ1739d)
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P40763
Reactivity Human, Mouse
Host Rabbit
Clonality Monoclonal
Clone Names EP2147Y
Calculated MW 88068 Da
Gene ID 6774
Other Names Signal transducer and activator of transcription 3, Acute-phase response factor, STAT3, APRF
Target/Specificity A synthetic phospho-peptide corresponding to residues surrounding tyrosine 705 of human Stat3 was used as immunogen.
Dilution WB~~1:10000~20000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsStat-3 Antibody Phospho (pY705) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAT3
Synonyms APRF
Function Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
Cellular Location Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 Identified in a complex with LYN and PAG1
Tissue Location Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
Research Areas
Citations (0)

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Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3 is activated by phosphorylation on tyrosine 705 which induces dimerization, nuclear translocation, and DNA binding Meanwhile, Stat3-activated transcription seems to be regulated by serine phosphorylation at serine 727 (4).


1. Heim, M.H. J. Recept. Signal Transduct. Res. 19: 75
2. Kisseleva, T. et al. Gene 285: 1
3. Bromberg, J.F. et al. Cell 98: 295
4. Wen, Z. et al. Cell 82: 241

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Cat# AJ1739d
(40 western blots)
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