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Stat-4 Antibody

Rabbit Monoclonal Antibody

  • WB - Stat-4 Antibody AJ1740a
    A. Western blot analysis on (A) Daudi, (B) K562 (C) HeLa cell lysates using anti-Stat4 RabMAb (Cat. #AJ1740a), 1:1000 dilution.
  • IHC - Stat-4 Antibody AJ1740a
    B. Immunohistochemical analysis of paraffin-embedded human tonsils using anti-Stat4 RabMAb (Cat. #AJ1740a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14765
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1900Y
Calculated MW 85941 Da
Gene ID 6775
Other Names Signal transducer and activator of transcription 4, STAT4
Target/Specificity A synthetic peptide corresponding to residues surrounding serine 721 of human Stat4 was used as immunogen.
Dilution WB~~1:10000~20000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsStat-4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAT4
Function Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.
Cellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation
Research Areas
Citations (0)

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Janus family tyrosine kinases (Jaks) and signal transducers and activators of transcription (STATs) are involved in mediating gene expression in response to cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the STATs. Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Stat4 is a signal transducer and activator of transcription. It is specifically involved in IL-12 signaling. Human Stat4 is phosphorylated on serine 721, tyrosine 355, and tyrosine 693. Phosphorylation at tyrosine leads to induces interaction with Stat3, while Stat4 phosphorylation at serine is linked to the requirement for maximal transcriptional activity (3).


1. Leonard, W.J. and J.J. O
2. O'Shea, J.J., et al J Clin Immunol. 17: 431
3. Kusaba H, et al. J Biol Chem 280, 1037-1043 (2005).

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Cat# AJ1740a
(40 western blots)
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