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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Stat-6 Antibody   

Stat-6 Antibody

Rabbit Monoclonal Antibody

  • WB - Stat-6 Antibody AJ1742a
    A. Western blot analysis on Daudi cell lysate using anti-Stat-6 RabMAb (Cat. #AJ1742a).
  • IF - Stat-6 Antibody AJ1742a
    B. Immunofluorescent staining of HeLa cells using anti-STAT-6 RabMAb (Cat. #AJ1742a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P42226
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names E265
Calculated MW 94135 Da
Gene ID 6778
Other Names Signal transducer and activator of transcription 6, IL-4 Stat, STAT6
Target/Specificity A synthetic peptide corresponding to residues in C-terminus of human Stat-6 was used as immunogen. The antibody does not cross-react with other Stat family members.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsStat-6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STAT6
Function Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Cellular Location Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation
Research Areas
Citations (0)

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Janus family tyrosine kinases (Jaks) and signal transducers and activators of transcription (STATs) are involved in mediating gene expression in response to cytokines and interferons. Jaks associate with cytokine receptors; upon ligand binding, Jaks phosphorylate the receptor. The phosphorylated receptors are bound by SH2-containing proteins, one class of which is the STATs. Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Stat6 is tyrosine phosphorylated in response to cellular interaction with IL-3 and IL-4 (3,4).


1. Leonard, W.J. and J.J. O
2. O'Shea, J.J., et al. Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency. J Clin Immunol. 17: 431
3. Hou, J., et al. An interleukin-4-induced transcription factor: IL-4 Stat. Science 265: 1701
4. Quelle, F.W., et al. Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. Mol. Cell. Biol. 15: 3336-3343 (1995).

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Cat# AJ1742a
(40 western blots)
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