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Stathmin Antibody Phospho (pS62)

Rabbit Monoclonal Antibody

  • WB - Stathmin Antibody Phospho (pS62) AJ1743d
    A.Western blot analysis on HeLa cell lysates using anti-Phospho-Stathmin (pS62) RabMAb (Cat. #AJ1743d), 1:10,000 dilution. Cells were either (A) untreated (B) treated with Calyculin A.
  • IHC - Stathmin Antibody Phospho (pS62) AJ1743d
    B. Immunohistochemical analysis of paraffin-embedded human brain tissue using Phospho-specific anti-Stathmin RabMAb (Cat. #AJ1743d).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P16949
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR1574
Calculated MW 17303 Da
Gene ID 3925
Other Names Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17, STMN1, C1orf215, LAP18, OP18
Target/Specificity A phospho-specific peptide corresponding to residues surrounding Serine 62 of human Stathmin was used as an immunogen. The antibody only detects Stathmin phosphorylated on Serine 62.
Dilution WB~~1:2500~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsStathmin Antibody Phospho (pS62) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name STMN1
Synonyms C1orf215, LAP18, OP18
Function Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Cellular Location Cytoplasm, cytoskeleton.
Tissue Location Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia
Research Areas
Citations (0)

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Stathmin (oncoprotein 18, op18) is a ubiquitous cytosolic phosphoprotein with various regulatory functions in cell proliferation, differentiation signaling, and activation (1). In particular, stathmin is involved in the regulation of tubulin dynamics through inhibition of microtubule formation and/or microtubule depolymerization. Stathmin interacts with soluble tubulins (α,β-tubulin) resulting in the formation of T2S complex which sequesters free tubulin, impeding tubulin formation (2). Stathmin activity is regulated through phosphorylation at Ser15, Ser24, Ser37 and Ser62 by various protein kinases (e.g. MAP-kinase, p34cdc2 kinase), weakening stathmins affinity to tubulin (3). A mutation on stathmin can lead to excess build up of mitotic spindle and with possible consequence of unregulated cell cycles seen in cancer cells (4). Stathmin is also known as the generic member of a protein family which includes neural proteins SCG10, SCLIP and RB3/RB3'/RB3. All members in this family exhibits tubulin binding ability.


1. Cassimeris L et al. Curr Opin in Cell Bio. 14:18-24, 2002
2. Clement MJ et al. Biochemistry. 44:14616-14625, 2005
3. Jourdain L et al. Biochemistry 36:10817-10821, 1997
4. Moreno FJ, Avila J, Mol Cell Biochem 183: 201-209, 1998

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Cat# AJ1743d
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