|Application ||WB, IHC, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||62847 Da|
|Other Names||Synapsin-2, Synapsin II, SYN2|
|Target/Specificity||A synthetic peptide corresponding to residues in human Synapsin II was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Synapsin II Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).|
|Cellular Location||Cell junction, synapse.|
|Tissue Location||Central and peripheral nervous systems.|
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Provided below are standard protocols that you may find useful for product applications.
The synapsins are a family of at least five proteins that are specifically associated with the cytoplasmic surface of synaptic vesicles (1, 2). They are neuron-specific phosphoproteins that selectively bind to small synaptic vesicles in the presynaptic nerve terminal (3). The synapsins are implicated in neurotransmitter release and synaptogenesis, processes believed to be aberrant in several neuropsychiatric diseases (1). Synapsin II has been reported to specifically be involved in the formation and maintenance of synapses in hippocampal neurons (4). It has also been found to play a distinct role in neuronal development, as a study reported that the deletion of synapsin II greatly retarded axon formation, and the deletion of synapsin I retarded synapse formation (5). Synapsin II was furthermore suggested to participate in cytoskeletal organization during the early stages of nerve cell development (6).
1. Porton B, et al. DNA Seq. 10(1):49-54,1999
2. Gerald Thiel, et al. Brain Pathology 3(1):87 - 95, 2008
3. Gerald Thiel, et al. The Journal of Bio.Chemistry 265(27):16527-16533, 1990
4. A. Ferreira, et al. PNAS 92(20):9225-9229, 1995
5. A. Ferreira, et al. Mol Med. 4(1): 22-28, 1998
6. A. Ferreira, et al. Science 264(5161):977 - 979, 1994
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