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Synaptojanin-2 Antibody

Rabbit Monoclonal Antibody

     
  • WB - Synaptojanin-2 Antibody AJ1751a
    A. Western blot analysis on SH-SY5Y cell lysates using anti-Synaptojanin 2 RabMAb (Cat. #AJ1751a), 1:500 dilution.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O15056
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2062Y
Calculated MW 165538 Da
Gene ID 8871
Other Names Synaptojanin-2, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 2, SYNJ2, KIAA0348
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Synaptojanin 2 is used as an immunogen.
Dilution WB~~1:500000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynaptojanin-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYNJ2
Synonyms KIAA0348
Function Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
Cellular Location Cytoplasm. Cell membrane. Membrane raft. Cell projection, axon {ECO:0000250|UniProtKB:O55207}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55207}. Note=Localizes at nerve terminals in brain and at bundles of microtubules surrounding the nucleus in the elongating spermatids corresponding to the manchette (By similarity). Translocates from the cytoplasm to membrane ruffles in a RAC1-dependent manner (PubMed:11084340)
Research Areas
Citations (0)

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Background

Synaptojanin is an inositol 5?0phosphatase and take part in membrane trafficking processes and signal transduction (1). Two isoform of Synaptojanin exists, Synaptojanin 1 (aka Synaptojanin) and Synaptojanin 2. Synaptojanin is mainly expressed in nerve terminals and is involved in clathrin-mediated synaptic vesicle recycling in neuronal cells (2). Ubiquitously expressed and with high catalytic domains homology to Synaptojanin, Synaptojanin 2 is considered as a Rac1 effector. Synaptojanin 2 possibly medicates the inhibitory effect of Rac1 on clathrin-mediated endocytosis. Synaptojanin 2 contributes to Rac1?s role in cell invasions and migration by regulation the formation of specialized membrane structures in ECM (invaodopoida and lamellipoida). Synaptojanin 2 is considered to be a novel target for therapeutic intervention in malignant tumors.

References

1. Nemoto Y, et al., ASNMN 272(49):30817-21, 1997.
2. Rusk N, et al., Curr Biol 13(8):659-63, 2003.

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Discontinued
Cat# AJ1751a
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