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Synaptojanin-2 Antibody

Rabbit Monoclonal Antibody

  • WB - Synaptojanin-2 Antibody AJ1751a
    A. Western blot analysis on SH-SY5Y cell lysates using anti-Synaptojanin 2 RabMAb (Cat. #AJ1751a), 1:500 dilution.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15056
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2062Y
Calculated MW 165538 Da
Gene ID 8871
Other Names Synaptojanin-2, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 2, SYNJ2, KIAA0348
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus of human Synaptojanin 2 is used as an immunogen.
Dilution WB~~1:500000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynaptojanin-2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYNJ2
Synonyms KIAA0348
Function Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.
Cellular Location Membrane. Note=Predominantly associated with the particulate fractions.
Research Areas
Citations (0)

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Synaptojanin is an inositol 5?0phosphatase and take part in membrane trafficking processes and signal transduction (1). Two isoform of Synaptojanin exists, Synaptojanin 1 (aka Synaptojanin) and Synaptojanin 2. Synaptojanin is mainly expressed in nerve terminals and is involved in clathrin-mediated synaptic vesicle recycling in neuronal cells (2). Ubiquitously expressed and with high catalytic domains homology to Synaptojanin, Synaptojanin 2 is considered as a Rac1 effector. Synaptojanin 2 possibly medicates the inhibitory effect of Rac1 on clathrin-mediated endocytosis. Synaptojanin 2 contributes to Rac1?s role in cell invasions and migration by regulation the formation of specialized membrane structures in ECM (invaodopoida and lamellipoida). Synaptojanin 2 is considered to be a novel target for therapeutic intervention in malignant tumors.


1. Nemoto Y, et al., ASNMN 272(49):30817-21, 1997.
2. Rusk N, et al., Curr Biol 13(8):659-63, 2003.

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Cat# AJ1751a
(40 western blots)
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