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Synaptophysin Antibody (C-term)

Rabbit Monoclonal Antibody

  • WB - Synaptophysin Antibody (C-term) AJ1752b
    A. Western blot analysis on PC12 cell lysate using anti-Synaptophysin RabMAb (Cat. #AJ1752b), dilution 1:10,000.
  • IHC - Synaptophysin Antibody (C-term) AJ1752b
    Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Synaptophysin RabMAb (cat.# AJ1752b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08247
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names YE269
Calculated MW 33845 Da
Gene ID 6855
Other Names Synaptophysin, Major synaptic vesicle protein p38, SYP
Target/Specificity A synthetic peptide corresponding to residues in C-terminus (cytoplasmic domain) of human Synaptophysin was used as immunogen. Predicted to cross-react with bovine, based on sequence homology.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynaptophysin Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYP
Function Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity).
Cellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Multi- pass membrane protein. Cell junction, synapse, synaptosome
Tissue Location Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype
Research Areas
Citations (0)

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Synaptophysin (SypI), also referred as p38 (1), constitutes approximately 7% of the total vesicle protein and is selectively associated with small synaptic vesicles (SSVs). Syp I contains four transmembrane regions and can be phosphorylated on its cytoplasmic C-terminus by both serine/threonine and tyrosine kinases (2). In addition to syp I, synaptic vesicles contain a highly homologous membrane protein named synaptoporin or synaptophysin II (Syp II) (3). While Syp I is ubiquitously expressed and present in virtually all synapses whereas Syp II is expressed at high levels only in selected neurons (4).


1. Navone F, Jahn R, Di Gioia G, Stukenbrok H, Greengard P, De Camilli P. J Cell Biol. 1986 Dec;103(6 Pt 1):2511-27
2. Linstedt, A. D., Vetter, M. L., Bishop, J. M. & Kelly, R. B. (1992) J. Cell Biol. 117, 1077-1084.
3. Knaus, P., Marqueze-Pouey, B., Scherer, H. & Betz, H. (1990) Neuron 5, 453-462.
4. Marqueze-Pouey, B., Wisden, W., Malosio, M. L. & Betz, H.(1991) J. Neurosci. 11, 3388-3397.

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Cat# AJ1752b
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