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Synip Antibody

Rabbit Monoclonal Antibody

  • WB - Synip Antibody AJ1754a
    A. Western blot analysis on human skeletal muscle lysate using anti-Synip RabMAb (Cat. #AJ1754a), dilution 1:1,000.
  • IHC - Synip Antibody AJ1754a
    B. Immunohistochemical analysis of paraffin-embedded human lung carcinoma using anti-Synip RabMAb (Cat. #AJ1754a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q6ZWJ1
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP302Y
Calculated MW 61662 Da
Gene ID 252983
Other Names Syntaxin-binding protein 4, Syntaxin 4-interacting protein, STX4-interacting protein, Synip, STXBP4
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of the PDZ domain of human Synip was used as immunogen. This antibody is predicted to detect the isoform 2 base on sequence analysis.
Dilution WB~~1:500~1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSynip Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).
Cellular Location Cytoplasm.
Research Areas
Citations (0)

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Synip (Syntaxin 4-Interacting protein) specifically binds to Syntaxin 4 and is uniquely expressed in muscle and adipose tissue. The binding interaction of Synip with syntaxin 4 is regulated by insulin, which also induces dissociation of the Synip-syntaxin 4 complex. Synip plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane and functions as a positive regulator of insulin-stimulated GLUT4 translocation. Synip also competes with VAMP2 but Not SNAP23 for binding to Syntaxin 4 (1-3).


1. Jeffrey E. Pessin, Debbie C. Thurmond, Jeffrey S. Elmendorf, Kenneth J. Coker, and Shuichi Okada, THE JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 274, No. 5, Issue of January 29, pp. 2593
2. Jing Min et al. Molecular Cell. Volume 3, Issue 6 , June 1999, Pages 751-760
3. J.A. Printen, M.J. Brady and A.R. Saltiel, Science 275 (1997), pp. 1475

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Cat# AJ1754a

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