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TAB1 Antibody

Rabbit Monoclonal Antibody

     
  • WB - TAB1 Antibody AJ1755a
    A. Western blot analysis on MCF-7 cell lysate using anti-TAB1 RabMAb (Cat. #AJ1755a), dilution 1:2000.
  • IHC - TAB1 Antibody AJ1755a
    B. Immunohistochemical staining of paraffin-embedded human tonsils using anti-TAB1 RabMAb (Cat. #AJ1755a).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession Q15750
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR635Y
Calculated MW 54644 Da
Gene ID 10454
Other Names TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1, TAB1, MAP3K7IP1
Target/Specificity A synthetic peptide corresponding to residues near the C-term of human TAB1 was used as an immunogen.
Dilution WB~~1:50000
IHC~~1:100~250
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTAB1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TAB1
Synonyms MAP3K7IP1
Function May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Background

TAB1, TAK1 binding protein, enhances activity of the plasminogen activator inhibitor 1 gene promoter, which is regulated by TGF-beta, and increases the kinase activity of TAK1. TAB1 may function as an activator of the TAK1 MAPKKK in TGF-beta signal transduction (1). Findings suggest that alternative activation pathways contribute to the biological responses of p38alpha to various stimuli. Interaction of p38alpha with TAB1 leads to autophosphorylation and activation of p38alpha (2).

References

1. Shibuya H, et al. Science 272(5265):1179-82, 1996.
2. Ge B, et al. Science 295(5558):1291-4

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Discontinued
Cat# AJ1755a
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