Tau Antibody Phospho (pS262)
Rabbit Monoclonal IgG
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|AJ1757c||100µl||2-3 days||$ 295.00||Add to cart|
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Tau Antibody Phospho (pS262) - Product Information
|Calculated MW||78928 Da|
|Gene ID 4137|
Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU
A phospho-specific peptide corresponding to residues surrounding Serine 262 of human Tau was used as an immunogen.
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Tau Antibody Phospho (pS262) is for research use only and not for use in diagnostic or therapeutic procedures.
Tau Antibody Phospho (pS262) - Protein Information
|Synonyms MAPTL, MTBT1, TAU|
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components
Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system
Tau Antibody Phospho (pS262) - Research Areas
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Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).
1. Goedert, M., et al. Proc Natl Acad Sci U S A. 85: 4051 2. Jakes, R., et al. EMBO J. 10: 2725 3. Maas, T., et al. J Biol Chem. 275: 15733 4. Singh, T.J., et al. Arch. Biochem. Biophys. 328: 43