- Antibodies
- New
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Tag
- Peptides
- Biological Process >
- Cellular Compartment >
- Disease >
- Molecular Function >
- Pathway Biocarta >
- Pathway KEGG >
- Pathway Panther >
- Tissue >
- Amino Acids
- Tag
- Biological Process >
- Proteins
- RNAi
- FL cDNA Clones
- Cell/Tissues/Lysates
Tau Antibody Phospho (pS262)Rabbit Monoclonal IgG
| Country | United States
Ordering Information
Australia Austria Belgium Brazil Bulgaria Canada China Croatia Cyprus Czech Republic Denmark Estonia Finland France Germany Greece Hungary Iceland India Indonesia Ireland Israel Italy Japan Korea Latvia Lithuania Luxembourg Macedonia Malaysia Malta Netherlands Norway Pakistan Poland Portugal Romania Serbia Singapore Slovakia Slovenia Spain Sweden Switzerland Taiwan Turkey United Kingdom United States Vietnam Others 
|
|||
|---|---|---|---|---|
| Catalog # | Size | Availability | Price | |
| AJ1757c | 100ul 400 ul | 2-3 days | $ 355.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
Tau Antibody Phospho (pS262) - Product info | |
| Application | WB
|
| Primary Accession | P10636 |
| Reactivity | Human |
| Clone Names | EPR2454 |
| Calculated MW | 78928 Da |
| Gene ID 4137 | |
| Target/Specificity A phospho-specific peptide corresponding to residues surrounding Serine 262 of human Tau was used as an immunogen. | |
| Dilution WB~~1:1000~10000 | |
| Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions Tau Antibody Phospho (pS262) is for research use only and not for use in diagnostic or therapeutic procedures. | |
Tau Antibody Phospho (pS262) - Protein Information | |
| Name MAPT | |
| Synonyms MAPTL, MTBT1, TAU | |
| Function Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization | |
| Cellular Location Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components | |
| Tissue Location Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system | |
Tau Antibody Phospho (pS262) - Related products
AP1425c: TAU (MAPT) Antibody (S720)
AP2040b: TAU Antibody (C-term)
AP3381a: Phospho-MAPT-S720 Antibody
LY12097a: MAPT Over-expression Lysate
BP1425c: MAPT Antibody (S720) Blocking Peptide
BP2040b: TAU Antibody (C-term) Blocking Peptide
BP3381a: Phospho-MAPT-S720 Antibody Blocking Peptide
AJ1757a: Tau Antibody Phospho (pS198)
AJ1757b: Tau Antibody Phospho (pS202)
AJ1757c: Tau Antibody Phospho (pS262)
AJ1757d: Tau Antibody Phospho (pS356)
AJ1757e: Tau Antibody Phospho (pS404)
Tau Antibody Phospho (pS262) - Application data
-
Western blot analysis on SH-SY5Y cell lysates using anti-Phospho-Tau (pS262) RabMAb (Cat. #AJ1757c), 1:2000 dilution. Cells were either (A) untreated (B) treated with Okadaic acid and Calyculin A.
Tau Antibody Phospho (pS262) - Research Areas
Abgent welcomes feedback from its customers.
If you have used an Abgent product and would like to share how it has performed, please click on the
"Submit Review" button and provide the requested information. Our staff will examine and post your
review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abgent.com.
Thank you for your support.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).
REFERENCES
1. Goedert, M., et al. Proc Natl Acad Sci U S A. 85: 4051 2. Jakes, R., et al. EMBO J. 10: 2725 3. Maas, T., et al. J Biol Chem. 275: 15733 4. Singh, T.J., et al. Arch. Biochem. Biophys. 328: 43
