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Tau Antibody Phospho (pS262)

Rabbit Monoclonal IgG

Produced using Abcam's RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487
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Ordering Information
Catalog # SizeAvailability Price  
AJ1757c 100µl 2-3 days
$ 295.00email & fax$ 280.25online
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Tau Antibody Phospho (pS262) - Product info

Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary AccessionP10636
ReactivityHuman
Clone NamesEPR2454
Calculated MW78928 Da
Gene ID 4137
Target/Specificity
A phospho-specific peptide corresponding to residues surrounding Serine 262 of human Tau was used as an immunogen.
Dilution
WB~~1:1000~10000
Format
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions
Tau Antibody Phospho (pS262) is for research use only and not for use in diagnostic or therapeutic procedures.

Tau Antibody Phospho (pS262) - Protein Information

Name MAPT
Synonyms MAPTL, MTBT1, TAU
Function
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Cellular Location
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components
Tissue Location
Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system

Tau Antibody Phospho (pS262) - Related products

AP1425c: TAU (MAPT) Antibody (S720)

AP2040B: TAU Antibody (C-term)

BP1425c: MAPT Antibody (S720) Blocking Peptide

BP2040b: TAU Antibody (C-term) Blocking Peptide

AJ1756a: Tau Antibody

AJ1756b: Tau Antibody

AJ1757a: Tau Antibody Phospho (pS198)

AJ1757b: Tau Antibody Phospho (pS202)

AJ1757d: Tau Antibody Phospho (pS356)

AJ1757e: Tau Antibody Phospho (pS404)

AJ1757f: Tau Antibody Phospho (pS422)

AN1240: Tau Antibody

AN1156: Phospho Ser416 Tau Antibody

AP50121: Phospho-Tau (Ser422) Antibody

AP50122: Phospho-Tau (Ser396) Antibody

AP50312: Phospho-Tau (Ser214) Antibody

AP50313: Phospho-Tau (Ser235) Antibody

AP50314: Phospho-Tau (Ser356) Antibody

AP50315: Phospho-Tau (Ser404) Antibody

AP50316: Phospho-Tau (Thr231) Antibody

AP50317: Phospho-Tau (Thr205) Antibody

Tau Antibody Phospho (pS262) - Research Areas

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BACKGROUND

Tau is a microtubule binding protein that promotes microtubule assembly and stability. Tau is found to be the major component of the paired helical filaments (PHFs) found in the brains of patients with Alzheimer disease (AD) (1,2). Tau is hyperphosphorylated in PHFs, and specific phosphorylation sites have been implicated in the loss of Taus association with the membrane cortex during AD disease state, including Ser 199/202, Thr 231, and Ser 393/404 (3). Glycogen synthase kinase-3, or GSK-3, phosphorylates Tau on Ser 396 (4).

REFERENCES

1. Goedert, M., et al. Proc Natl Acad Sci U S A. 85: 4051 2. Jakes, R., et al. EMBO J. 10: 2725 3. Maas, T., et al. J Biol Chem. 275: 15733 4. Singh, T.J., et al. Arch. Biochem. Biophys. 328: 43