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TCF-3 Antibody

Rabbit Monoclonal Antibody

  • WB - TCF-3 Antibody AJ1759a
    A. Western blot analysis on (A) A431 and (B) fetal small intestine lysates using anti-TCF-3 RabMAb (Cat. #AJ1759a), dilution 1:2000.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9HCS4
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2031
Calculated MW 62631 Da
Gene ID 83439
Other Names Transcription factor 7-like 1, HMG box transcription factor 3, TCF-3, TCF7L1, TCF3
Target/Specificity A synthetic peptide corresponding to residues in human TCF-3 was used as an immunogen.
Dilution WB~~1:1000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTCF-3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCF7L1
Synonyms TCF3
Function Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
Cellular Location Nucleus.
Tissue Location Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium
Research Areas
Citations (0)

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T-cell factor 3 (transcription factor 7-like 1, TCF-3) is a component of the Wnt signaling pathway, which functions in CNS patterning, proliferation and neurogenesis, and a dominant downstream effector in embryonic stem cells (ESCs). TCF-3 binds to and represses the Oct4 promoter, and plays an important role in modulating the appropriate level of gene transcription in ESCs and during embryonic development (1, 2). TCF-3 is necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. It down-regulates NQO1, leading to increased mitomycin c resistance. It is detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium (2).


1. Tam WL, et al. Stem Cells. 26(8):2019-31, 2008
2. The UniProt Consortium, The Universal Prtoein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008)
3. Gribble SL, et al. Development 136(5):781-9, 2009

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Cat# AJ1759a
(40 western blots)
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