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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   TCP1 alpha Antibody   

TCP1 alpha Antibody

Rabbit Monoclonal IgG

  • WB - TCP1 alpha Antibody AJ1761a
    Western blot analysis on (A) HeLa, (B) ECV-304, (C) A459, and (D) 293T cell lysates using anti-TCP1 Alpha RabMAb (Cat. #AJ1761a).
  • IHC - TCP1 alpha Antibody AJ1761a
    Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-TCP1 alpha RabMAb (Cat. #AJ1761a).
  • IHC - TCP1 alpha Antibody AJ1761a
    Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-TCP1 alpha RabMAb (Cat. #AJ1761a).
  • IF - TCP1 alpha Antibody AJ1761a
    Immunofluorescent staining of HeLa cells using anti-TCP-1 alpha RabMAb (Cat. #AJ1761a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P17987
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR4081
Calculated MW 60344 Da
Gene ID 6950
Other Names T-complex protein 1 subunit alpha, TCP-1-alpha, CCT-alpha, TCP1, CCT1, CCTA
Target/Specificity A synthetic peptide corresponding to residues near the N-terminus in human TCP1 Alpha was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTCP1 alpha Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCP1
Synonyms CCT1, CCTA
Function Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Research Areas
Citations (0)

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T-complex polypeptide 1 subunit alpha (TCP1 alpha) is a cytosolic molecular chaperone that belongs to the chaperonin-containing TCP1 (CCT) complex (1). The CCT complex is composed of eight subunits that assist in the folding of actin, tubulin, and other cytosolic proteins (1). The sequence differences among the CCT subunits are located mainly in their apical domains, suggesting some degree of specificity towards substrate binding (2). TCP1 alpha plays a role in the folding of newly translated proteins in the cytosol (3). Major cytoskeletal proteins such as actin and tubulin, depend on CCT to maintain the integrity of the microfilament and microtubule-based cytoskeletal systems (4). Overexpression of the TCP1 alpha in neurons may reduce the formation of pathogenic conformations of the hungtingtin protein associated with Huntington's disease (5).


1. Yokota et al. Eur J Biochem. 268(17):4664-73, 2001. 2. Llorca et al. EMBO J. 20(15):4065-75, 2001. 3. Online Mendelian Inheritance in Man, OMIM (TM). Johns Hopkins University, Baltimore, MD. MIM Number: { 186980}: {5/23/2003}: . World Wide Web URL: 4. Brackley et al. Cell Stress Chaperones. 14(1):23-31, 2009. 5. Tam et al. Nat Cell Biol. 8(10):1155-62, 2006.

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Cat# AJ1761a
(40 western blots)
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