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TFF1 Antibody

Rabbit Monoclonal IgG

  • WB - TFF1 Antibody AJ1765a
    Western blot analysis on (A) human stomach and (B) MCF-7 cell lysates using anti-TFF1 RabMAb (Cat. #AJ1765a).
  • IHC - TFF1 Antibody AJ1765a
    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-TFF1 RabMAb (Cat. #AJ1765a).
  • IHC - TFF1 Antibody AJ1765a
    Immunohistochemical analysis of paraffin-embedded human stomach tissue using anti-TFF1 RabMAb (Cat. #AJ1765a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04155
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3972
Calculated MW 9150 Da
Gene ID 7031
Other Names Trefoil factor 1, Breast cancer estrogen-inducible protein, PNR-2, Polypeptide P1A, hP1A, Protein pS2, TFF1, BCEI, PS2
Target/Specificity A synthetic peptide corresponding to residues in human TFF1 was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTFF1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TFF1
Synonyms BCEI, PS2
Function Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.
Cellular Location Secreted
Tissue Location Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level) Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at protein level)
Research Areas
Citations (0)

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Trefoil factor 1 (TFF1), a member of the trefoil factor family, is a stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents (1). It belongs to a family of abundant GI3 peptides with a distinct 3-loop structure formed by a highly conserved motif of cysteine disulfide bonds, which confer them with luminal stability (2). TFF peptides, closely associated with mucins, are mainly synthesized and secreted by mucin-secreting epithelial cells lining the gastrointestinal tract (3). It is specifically found in the stomach, with highest expression levels in the upper gastric mucosal cells (1). TFF1 is most strongly expressed in pancreas, large bowel, and breast cancer (1). In breast cancer, its regulation by estrogen is an indicator of estrogen receptor (ER) functionality (4).


1. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 37:D169-D174(2009). 2. Yamachika T et al. Clinical Cancer Res. 8:1092-1099, 2002. 3. Hoffmann W et al. Int Rev Cytol. 213:147-81, 2002. 4. Abdou AG et al. APMIS. 116(11):961-71, 2008.

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Cat# AJ1765a
(40 western blots)
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