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Thymidine Kinase 1 Antibody

Rabbit Monoclonal Antibody

  • WB - Thymidine Kinase 1 Antibody AJ1768a
    A.Western blot analysis on Molt-4 cell lysate using anti-Thymidine Kinase 1 RabMAb (Cat. #AJ1768a), dilution 1:50,000.
  • IHC - Thymidine Kinase 1 Antibody AJ1768a
    B.Immunohistochemical analysis of paraffin-embedded human tonsils using anti-Thymidine Kinase 1 RabMAb (Cat. #AJ1768a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04183
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3193
Calculated MW 25469 Da
Gene ID 7083
Other Names Thymidine kinase, cytosolic, TK1
Target/Specificity A synthetic peptide corresponding to residues in human Thymidine Kinase 1 was used as an immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsThymidine Kinase 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TK1
Cellular Location Cytoplasm.
Citations (0)

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Cytosolic thymidine kinase 1, TK1, is a well known cell-cycle-regulated enzyme of importance in nucleotide metabolism as well as an activator of antiviral and anticancer drugs (1). TK1 catalyzes the ATP-dependent phosphorylation of thymidine to thymidine 5'-monophosphate, which is subsequently converted to thymidine 5'-triphosphate and utilized for DNA synthesis. In terminally differentiating cells, such as cardiac muscle cells, the cessation of DNA synthesis and withdrawal from the cell cycle are accompanied by the loss of TK1 activity (2). TK1 is a key enzyme of the salvage pathway for pyrimidine deoxyribonucleotide synthesis in a variety of organisms (3). Two forms have been identified in animal cells, one in cytosol and one in mitochondria. Activity of the cytosolic enzyme is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells (4).


1. Welin M, et al. PNAS 101:17970-17975, 2004
2. Bradshaw H Jr., et al. Molecular and Cellular Biology 4(11):2316-2320, 1984
3. James L., et al. The Journal of Biological Chemistry 263(1):375-382,1988
4. The UniProt Consortium, The Universal Protein Resource (UniProt), Nucleic Acids Res. 36:D190-D195 (2008)

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Cat# AJ1768a
(40 western blots)
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