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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Thyroglobulin Antibody   

Thyroglobulin Antibody

Rabbit Monoclonal

     
  • WB - Thyroglobulin Antibody AJ1769a
    A.Western blot analysis on human thyroid lysate using anti-Thyroglobulin RabMAb (Cat. #AJ1769a).
  • IHC - Thyroglobulin Antibody AJ1769a
    B. Immunohistochemical analysis of paraffin-embedded human papillary thyroid carcinoma using anti-Thyroglobulin RabMAb (Cat. #AJ1769a).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P01266
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR3614
Calculated MW 304790 Da
Gene ID 7038
Other Names Thyroglobulin, Tg, TG
Target/Specificity A synthetic peptide corresponding to residues in human Thyroglobulin was used as an immunogen.
Dilution WB~~1:10000~20000
IHC~~1:2500~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsThyroglobulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TG
Function Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Cellular Location Secreted.
Tissue Location Thyroid gland specific.
Research Areas
Citations (0)

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Background

Thyroglobulin (TG) is a dimeric glycoprotein specific to the thyroid gland which belongs to the type-B carboxylesterase/lipase family. It is the precursor of the iodinated thyroid hormones triiodothyronine (T3) and thyroxine (T4) (1, 2). Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (2), and defective or impaired TG synthesis usually results in congenital goitrous hypothyroidism, virtual absence of TG in thyroid tissue, and the presence of an elevated concentration of iodoalbumin. The final result of these abnormalities is a decreased rate of T3 and T4 synthesis (3).

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Discontinued
Cat# AJ1769a
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