|Calculated MW||304790 Da|
|Other Names||Thyroglobulin, Tg, TG|
|Target/Specificity||A synthetic peptide corresponding to residues near the C-term in human Thyroglobulin was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Thyroglobulin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).|
|Tissue Location||Thyroid gland specific.|
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Provided below are standard protocols that you may find useful for product applications.
Thyroglobulin (TG) is a dimeric glycoprotein specific to the thyroid gland which belongs to the type-B carboxylesterase/lipase family. It is the precursor of the iodinated thyroid hormones triiodothyronine (T3) and thyroxine (T4) (1, 2). Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (2), and defective or impaired TG synthesis usually results in congenital goitrous hypothyroidism, virtual absence of TG in thyroid tissue, and the presence of an elevated concentration of iodoalbumin. The final result of these abnormalities is a decreased rate of T3 and T4 synthesis (3).
1. Malthiery Y., et al. Eur. J. Biochem. 147:53-58, 1985 2. The UniProt Consortium, The Universal Protein Resource (UniProt). Nucleic Acids Res. 36:D190-D195 (2008) 3. Targovnik HM, et al. J Clin Endocrinol Metab. 77(1):210-5, 1993
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