|Calculated MW||23171 Da|
|Other Names||Metalloproteinase inhibitor 1, Erythroid-potentiating activity, EPA, Fibroblast collagenase inhibitor, Collagenase inhibitor, Tissue inhibitor of metalloproteinases 1, TIMP-1, TIMP1, CLGI, TIMP|
|Target/Specificity||A synthetic peptide corresponding to residues in the C-terminal region of human TIMP-1 was used as immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIMP-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.|
|Tissue Location||Detected in rheumatoid synovial fluid (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a stromal factor which forms complexes with various members of matrix metalloproteinases (MMPs) and irreversibly inactivates them. A multifunctional glycoprotein, TIMP-1 is one of the four members of TIMP family (TIMP 1-4) which exhibits 50% sequence similarity and expressed in wide variety of cells (1). TIMP-1 binds non-covalently in a 1:1 stoichiometric fashion to the active form of MMPs thereby inhibiting the proteolytic activity of these enzymes. Including inhibitory function, other studies have proposed growth protion, anti-apoptotic, anti- and pro-angiogenic functions for TIMP-1. TIMP-1 expression has been observed in poor clinical outcome in many cancer types, making it ideal prognostic marker in various cancer (2).
1. Schrohl AS et al Endocrine-Related Cancer 12 (2) 215-227, 2005.
2. Schrohl AS et al. Clinical Cancer Research 10 2289
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