|Calculated MW||22297 Da|
|Other Names||Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA, TNFB, TNFSF1|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-term of human TNF-β was used as immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TNF beta Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.|
|Cellular Location||Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated|
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Provided below are standard protocols that you may find useful for product applications.
Tumor necrosis factor beta (TNF beta, lymphotoxin alpha, LTA) is a multifunctional pro-inflammatory cytokine involved in the immune system and local inflammatory response (1). A member of the tumor necrosis factor family, TNF beta is secreted by mitogen-activated peripheral blood leukocytes (T and B lymphocytes) and cell lines from hematopoietic origin (2). In its homotrimeric form, TNF beta binds to TNFR1 and TNFR2, which activates various cellular responses, including cytotoxic effects on a wide range of tumor cells. Similar to TNF alpha, TNF beta is involved in the regulation of cell proliferation, differentiation, and apoptosis. TNF beta activity has been implicated in the pathogenesis of in various diseases, such as coronary heart disease, schizophrenia, and chronic obstructive pulmonary disease (3).
1. Matsuyama N et al. FEBS Letters 302(2): 141-144, 1992.
2. Ruff MR. and Gill'ord GE, TNF in Lymphokincs. vol. 2 235-275. Academic Press. New York, 1981.
3. Seifart C et al. Tissue Antigens 65(1): 93, 2005.
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