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TNFR1 Antibody

Rabbit Monoclonal Antibody

     
  • WB - TNFR1 Antibody AJ1778a
    A. Western blot analysis on human brain tissue lysate using anti-TNFR1 Rabbit Monoclonal (Cat. #AJ1778a), dilution 1:500.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P19438
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP1651AY
Calculated MW 50495 Da
Gene ID 7132
Other Names Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor 1, TNF-R1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55, p60, CD120a, Tumor necrosis factor receptor superfamily member 1A, membrane form, Tumor necrosis factor-binding protein 1, TBPI, TNFRSF1A, TNFAR, TNFR1
Target/Specificity A synthetic peptide corresponding to the extracellular portion of human TNFR1 was used as immunogen.
Dilution WB~~1:500
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTNFR1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TNFRSF1A
Synonyms TNFAR, TNFR1
Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Cellular Location Cell membrane; Single-pass type I membrane protein Golgi apparatus membrane; Single- pass type I membrane protein Secreted. Note=A secreted form is produced through proteolytic processing
Research Areas
Citations (0)

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Background

Tumor necrosis factor receptor 1 (TNFR1) is a receptor for tumor necrosis factor alpha (TNF-α), a mulitifunctional proinflammatory cytokine. Produced in activated monocytes, TNF-α has effects on lipid metabolism, coagulation, insulin resistance, and endothelial function (1). TNFR1 is activated by binding to TNF- α or homotrimeric lymphotoxin-α, which leads to recruitment of caspase 8 to the activated receptor by FADD. This formation of death inducing signaling complex (DISC) lead to caspase 8 proteolytic activation and cascade of caspases mediating apoptosis (2).

References

1. Brenner DA, et al., Nature (6208):661-3, 1989.
2. Bouwmeester T, et al, Nat Cell Biol (2):87-9, 2004.

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Discontinued
Cat# AJ1778a
Size:
(40 western blots)
Alternative Products:

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