|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||50985 Da|
|Other Names||Tryptophan 5-hydroxylase 1, Tryptophan 5-monooxygenase 1, TPH1, TPH, TPRH, TRPH|
|Target/Specificity||A synthetic peptide corresponding to residues near the C-terminus of human TPH1 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TPH1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||TPH, TPRH, TRPH|
|Tissue Location||Isoform 2 seems to be less widely expressed than isoform 1|
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Provided below are standard protocols that you may find useful for product applications.
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and might be related to the pathogenesis of major depression (MD). Two isoforms are known, TPH1 and TPH2. (1). TPH1 is phosphorylated by cAMP-dependent protein kinase A (2). Recently, it has been shown that expression of the TPH1 gene is increased in lungs and pulmonary endothelial cells from patients with idiopathic pulmonary arterial hypertension. Results indicate that TPH1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxia-induced pulmonary vascular remodeling. In addition, the results suggest that, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy (3).
1. Gizatullin R, et al. Biol Psychiatry 59(4):295-300, 2006.
2. McKinney J, et al. J Neurochem 92(2):311-20, 2005.
3. Morecroft I, et al. Hypertension 49(1):232-6, 2007
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