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TPPP Antibody

Rabbit Monoclonal Antibody

  • WB - TPPP Antibody AJ1786a
    A. Western blot analysis on (A) fetal brain, (B) SH-SY5Y, (C) mouse brain and (D) rat brain lysates using anti-TPPP RabMAb (Cat. #AJ1786a), dilution 1:1000.
  • IHC - TPPP Antibody AJ1786a
    B. Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-TPPP RabMAb (Cat. #AJ1786a).
  • IF - TPPP Antibody AJ1786a
    C. Immunofluorescent staining of SH-SY5Y cells using anti-TPPP RabMAb (Cat. #AJ1786a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O94811
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EPR3316
Calculated MW 23694 Da
Gene ID 11076
Other Names Tubulin polymerization-promoting protein, TPPP, 25 kDa brain-specific protein, TPPP/p25, p24, p25-alpha, TPPP, TPPP1
Target/Specificity A synthetic peptide corresponding to residues in human TPPP was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTPPP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms TPPP1
Function May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Tubulin polymerization-promoting protein (TPPP) is an unfolded brain-specific protein that interacts with the tubulin/microtubule system, and is enriched in human pathological brain inclusions (1). TPPP can induce aggregation of alpha-synuclein, and can accumulate in oligodendroglial cell bodies containing fibrillized alpha-synuclein multiple system atrophy (MSA), a neurodegenerative disease. TPPP is a constituent of myelin and a high-affinity ligand for myelin basic protein (MBP), and has been shown to colocalize with MBP in myelin in normal human brains (2).


1. Hlavanda E, et al. J Biol Chem. 282(40):29531-9, 2007
2. Song YJ, et al. Am J Pathol. 171(4):1291-303, 2007

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Cat# AJ1786a
(40 western blots)
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