|Application ||WB, IHC, IF|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||23694 Da|
|Other Names||Tubulin polymerization-promoting protein, TPPP, 25 kDa brain-specific protein, TPPP/p25, p24, p25-alpha, TPPP, TPPP1|
|Target/Specificity||A synthetic peptide corresponding to residues in human TPPP was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TPPP Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Tubulin polymerization-promoting protein (TPPP) is an unfolded brain-specific protein that interacts with the tubulin/microtubule system, and is enriched in human pathological brain inclusions (1). TPPP can induce aggregation of alpha-synuclein, and can accumulate in oligodendroglial cell bodies containing fibrillized alpha-synuclein multiple system atrophy (MSA), a neurodegenerative disease. TPPP is a constituent of myelin and a high-affinity ligand for myelin basic protein (MBP), and has been shown to colocalize with MBP in myelin in normal human brains (2).
1. Hlavanda E, et al. J Biol Chem. 282(40):29531-9, 2007
2. Song YJ, et al. Am J Pathol. 171(4):1291-303, 2007
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