|Application ||WB, IHC|
|Calculated MW||24008 Da|
|Other Names||Troponin I, cardiac muscle, Cardiac troponin I, TNNI3, TNNC1|
|Target/Specificity||A synthetic peptide corresponding to residues near the N-terminus of human Troponin 1 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Troponin-1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.|
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Provided below are standard protocols that you may find useful for product applications.
Troponin I, one of 3 subunits that form the troponin complex of the thin filaments of striated muscle, is the inhibitory component of troponin, the thin filament regulatory complex in striated muscle. Separate genes encode cardiac-specific fast and slow skeletal-specific isoforms of this protein (1). Unlike other contractile proteins, the cardiac isoform of troponin I (TnIc) is expressed only in cardiac muscle and therefore offers a model for cardiac-specific expression. It is also subject to developmental regulation with increased expression occurring at the time of birth (2). TnIc, a sensitive and specific marker of myocardial cell injury, is useful in diagnosing and assessing prognosis in acute coronary syndromes. Studies report that TnIc is elevated in severe heart failure and may predict adverse outcomes (3).
1. Hunkeler NM, et al. Circ Res. 69(5):1409-14, 1991.
2. Bhavsar PK, et al. Genomics 35(1):11-23, 1996.
3. Horwich TB, et al. Circulation 108(7):833-8, 2003.
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