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TSC1/Hamartin Antibody

Rabbit Monoclonal Antibody

  • WB - TSC1/Hamartin Antibody AJ1797a
    A. Western blot analysis on HeLa cell lysate using anti-TSC1/Hamartin RabMAb (Cat. #AJ1797a), dilution 1:20,000
  • IHC - TSC1/Hamartin Antibody AJ1797a
    B. Immunohistochemical analysis of paraffin-embedded human kidneys using anti-TSC-1 RabMAb (Cat. #AJ1797a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92574
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP318Y
Calculated MW 129767 Da
Gene ID 7248
Other Names Hamartin, Tuberous sclerosis 1 protein, TSC1, KIAA0243, TSC
Target/Specificity A synthetic peptide corresponding to C-terminal residues of human TSC1/Hamartin was used as an immunogen.
Dilution WB~~1:1000~10000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTSC1/Hamartin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TSC1
Synonyms KIAA0243, TSC
Function In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
Cellular Location Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
Tissue Location Highly expressed in skeletal muscle, followed by heart, brain, placenta, pancreas, lung, liver and kidney. Also expressed in embryonic kidney cells
Research Areas
Citations (0)

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Tuberous sclerosis complexes-1 (TSC1 also known as Hamartin) is a tumor suppressor that form a complex with TSC2 (Tuberin). This complex is known to control various cellular functions including cell cycle, endocytosis, adhesion, and transcription (1). The TSC1/TSC2 complex inhibits phosphorylation of S6kinase and 4E-BP1 through inactivation of mTOR (2). Recently it has been shown that TSC1/Hamartin is localized to the centrosome and negatively regulates Plk1 implicating TSC1/hamartin to the regulation of centrosome duplication (3). Tuberous sclerosis (TSC), an autosomal dominant disorder that affects 1 in 6000 individuals, is caused by a mutation in either the TSC1 or TSC2 tumor suppressor gene.


1. Lamb,et al. Nature Cell Biol 2:281-287
2. Manning BD, et al. Molec. Cell 10:151-162, 2002.
3. Astrinidis A, Senapedis W, et al. Hum Mol Genet 15:287-297, 2005.

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Cat# AJ1797a
(40 western blots)
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