|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||133650 Da|
|Other Names||Non-receptor tyrosine-protein kinase TYK2, TYK2|
|Target/Specificity||A synthetic peptide corresponding to residues near the C-terminus of human Tyk2 was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Tyk2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.|
|Tissue Location||Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines|
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Provided below are standard protocols that you may find useful for product applications.
Novel non-receptor tyrosine-protein kinase, Tyk2, belongs to the tyrosine protein kinase family and plays a role in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Tyk2 is believed to phosphorylate the interferon-alpha/beta receptor alpha chain (1). It has been shown that Tyk2 links the interferon alpha/beta receptor to the cytoplasmic transcription factor that mediates activation of interferon-responsive genes (2).
1. Firmback-Kraft I, et al. Oncogene 5(9):1329-36, 1990.
2. Velazquez L, et al. Cell 70(2):313-22, 1992.
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