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Tyk2 Antibody

Rabbit Monoclonal Antibody

     
  • WB - Tyk2 Antibody AJ1801a
    A. Western blot analysis on Raji cell lysate using anti-Tyk2 RabMAb (Cat. #AJ1801a), dilution 1:50,000.
  • IHC - Tyk2 Antibody AJ1801a
    B. Immunohistochemical staining of paraffin-embedded human liver using anti-Tyk2 RabMAb (Cat. #AJ1801a).
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P29597
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1127Y
Calculated MW 133650 Da
Gene ID 7297
Other Names Non-receptor tyrosine-protein kinase TYK2, TYK2
Target/Specificity A synthetic peptide corresponding to residues near the C-terminus of human Tyk2 was used as an immunogen.
Dilution WB~~1:1000~5000
IHC~~1:100~250
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTyk2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TYK2
Function Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Tissue Location Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines
Research Areas
Citations (0)

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Background

Novel non-receptor tyrosine-protein kinase, Tyk2, belongs to the tyrosine protein kinase family and plays a role in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Tyk2 is believed to phosphorylate the interferon-alpha/beta receptor alpha chain (1). It has been shown that Tyk2 links the interferon alpha/beta receptor to the cytoplasmic transcription factor that mediates activation of interferon-responsive genes (2).

References

1. Firmback-Kraft I, et al. Oncogene 5(9):1329-36, 1990.
2. Velazquez L, et al. Cell 70(2):313-22, 1992.

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Discontinued
Cat# AJ1801a
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