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TH Antibody

Rabbit Monoclonal Antibody

  • WB - TH Antibody AJ1803b
    A. Western blot analysis on human adrenal gland lysate using anti- Tyrosine 3-Hydroxylase RabMAb (Cat. #AJ1803b), dilution 1:500.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07101
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP1533Y
Calculated MW 58600 Da
Gene ID 7054
Other Names Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH, TH, TYH
Target/Specificity A synthetic peptide corresponding to residues surrounding serine 70 human Tyrosine 3-Hydroxylase was used as an immunogen.
Dilution WB~~1:500~1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTH Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TH
Synonyms TYH
Function Plays an important role in the physiology of adrenergic neurons.
Tissue Location Mainly expressed in the brain and adrenal glands
Research Areas
Citations (0)

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Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine biosynthesis. Functional polymorphisms of the TH gene may be involved in the pathogenesis of neuropsychiatric diseases such as schizophrenia, affective disorders, and Parkinsonism (1). Catecholamines that are produced by the catecholamine biosynthetic pathway, in which tyrosine hydroxylase catalyzes the initial, rate-limiting step, include dopamine, noradrenaline, and adrenaline. These 3 catecholamines are important neurotransmitters and hormones that regulate visceral functions, motor coordination, and arousal in adults. The TH gene becomes transcriptionally active in developing neuroblasts during midgestation of rodent embryos, before the onset of neurotransmission (2). Tyrosine hydroxylase catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-DOPA), the rate-limiting step in the biosynthesis of dopamine (3).


1. Knappskog PM, et al. Hum Mol Genet 4(7):1209-12, 1995
2. Zhou, QY et al. Nature 374:640-643, 1995
3. Kunugi H, et al. Am J Med Genet 81(2):131-3, 1998

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Cat# AJ1803b
(40 western blots)
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