|Reactivity||Human, Mouse, Rat|
|Calculated MW||58600 Da|
|Other Names||Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH, TH, TYH|
|Target/Specificity||A synthetic peptide corresponding to residues surrounding serine 70 human Tyrosine 3-Hydroxylase was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TH Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the physiology of adrenergic neurons.|
|Tissue Location||Mainly expressed in the brain and adrenal glands|
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Provided below are standard protocols that you may find useful for product applications.
Tyrosine hydroxylase (TH) is a rate-limiting enzyme for catecholamine biosynthesis. Functional polymorphisms of the TH gene may be involved in the pathogenesis of neuropsychiatric diseases such as schizophrenia, affective disorders, and Parkinsonism (1). Catecholamines that are produced by the catecholamine biosynthetic pathway, in which tyrosine hydroxylase catalyzes the initial, rate-limiting step, include dopamine, noradrenaline, and adrenaline. These 3 catecholamines are important neurotransmitters and hormones that regulate visceral functions, motor coordination, and arousal in adults. The TH gene becomes transcriptionally active in developing neuroblasts during midgestation of rodent embryos, before the onset of neurotransmission (2). Tyrosine hydroxylase catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-DOPA), the rate-limiting step in the biosynthesis of dopamine (3).
1. Knappskog PM, et al. Hum Mol Genet 4(7):1209-12, 1995
2. Zhou, QY et al. Nature 374:640-643, 1995
3. Kunugi H, et al. Am J Med Genet 81(2):131-3, 1998
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