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Vitamin D-binding protein Antibody

Rabbit Monoclonal Antibody

     
  • WB - Vitamin D-binding protein Antibody AJ1816a
    A. Western blot analysis on Human Plasma using anti-VDBP RabMAb (Cat. #AJ1816a), dilution 1:20,000
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P02774
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EPR2922Y
Calculated MW 52964 Da
Gene ID 2638
Other Names Vitamin D-binding protein, DBP, VDB, Gc-globulin, Group-specific component, GC
Target/Specificity A synthetic peptide corresponding to residues within human VDBP was used as an immunogen.
Dilution WB~~1:1000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVitamin D-binding protein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GC
Function Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.
Cellular Location Secreted.
Tissue Location Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine
Research Areas
Citations (0)

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Background

Vitamin D-binding protein (VDBP, DBP, Gc) is a multifunctional plasma protein that has many physiologically important functions, ranging from transporting vitamin D3 metabolites, binding and sequestering globular actin and binding fatty acids to functioning in the immune system. It is a member of a multigene family including alpha-fetoprotein and albumin. It is a serum glycoprotein that reversibly binds and transports vitamin D and its metabolites to target cells. VDBP has a triple domain modular structure with extensive disulfide bonding that is characteristic of this protein family. VDBP receptors are constitutively expressed by malignant B-cells and in a transitory form by normal B-lymphocytes undergoing mitogen-induced activation (1-4).

References

1. Cooke NE, et al. J Clin Invest 76(6):2420-4, 1985
2. Verboven C, et al. Nat. Struct Biol 9(2):131-6, 2002
3. Zhang J, et al. The Journal of biological chemistry 279(51):53282-53287, 2004
4. Esteban C, et al. J Biol Chem. 267(14):10177-83, 1992

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Discontinued
Cat# AJ1816a
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