|Application ||WB, IHC|
|Calculated MW||52964 Da|
|Other Names||Vitamin D-binding protein, DBP, VDB, Gc-globulin, Group-specific component, GC|
|Target/Specificity||A synthetic peptide corresponding to residues within human VDBP was used as an immunogen.|
|Format||50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Vitamin D-binding protein Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
Vitamin-D binding protein (VDBP, DBP, Gc) is a multifunctional plasma protein that has many physiologically important functions, ranging from transporting vitamin D3 metabolites, binding and sequestering globular actin and binding fatty acids to functioning in the immune system. It is a member of a multigene family including alpha-fetoprotein and albumin. It is a serum glycoprotein that reversibly binds and transports vitamin D and its metabolites to target cells. VDBP has a triple domain modular structure with extensive disulfide bonding that is characteristic of this protein family. VDBP receptors are constitutively expressed by malignant B-cells and in a transitory form by normal B-lymphocytes undergoing mitogen-induced activation (1-4).
1. Cooke NE, et al. J Clin Invest 76(6):2420-4, 1985
2. Verboven C, et al. Nat. Struct Biol 9(2):131-6, 2002
3. Zhang J, et al. The Journal of biological chemistry 279(51):53282-53287, 2004
4. Esteban C, et al. J Biol Chem. 267(14):10177-83, 1992
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