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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Vitronectin Antibody   

Vitronectin Antibody

Rabbit Monoclonal Antibody

  • WB - Vitronectin Antibody AJ1817a
    A. Western blot analysis on human serum using anti-Vitronectin RabMAb (Cat. #AJ1817a), dilution 1:20,000
  • IHC - Vitronectin Antibody AJ1817a
    B. Immunohistochemical analysis of paraffin-embedded lung tissue using anti-Vitronectin RabMAb (Cat. #AJ1817a).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04004
Reactivity Human
Host Rabbit
Clonality Monoclonal
Clone Names EP781Y
Calculated MW 54306 Da
Gene ID 7448
Other Names Vitronectin, VN, S-protein, Serum-spreading factor, V75, Vitronectin V65 subunit, Vitronectin V10 subunit, Somatomedin-B, VTN
Target/Specificity A synthetic peptide corresponding to residues near the hemopexin-like 1 domain of human Vitronectin was used as immunogen.
Dilution WB~~1:20000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVitronectin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VTN
Function Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Cellular Location Secreted, extracellular space.
Tissue Location Plasma.
Research Areas
Citations (0)

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Vitronectin also called serum spreading factor or complement S-protein, is a member of the pexin family (1). Found in serum and in tissues, Vitronectin exist in two forms; as a single chain (75kDa) and as a clipped form composed of two chains (65kDa and 10kDa). Vitronectin promotes cell adhesion, spreading and migration through specific interactions with cellular integrins, and inhibits cytolysis by the complement C5b-9 complex (2-4). Vitronectin also interacts with several critical proteins that regulate thrombosis and fibrinolysis. Vitronectin is phosphorylated by PKA and CKII (5).


1. Jenne, D.; Stanley, K. K. EMBO J. 4: 3153-3157, 1985.
2. Waltz DA, and Chapman HA, JBC 269:14746-14750, 1994
3. Seiffert D and Smith JW, JBC 272:13705-13710, 1997
4. Tomasini, BR, and Mosher DF, Hemostasis and Thrombosispp. 269-305, 1991.
5. Korc-Grodzicki, B et al, Anal. Biochem. 188: 288-294, 1990

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Cat# AJ1817a
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