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Vitronectin Antibody

Rabbit Monoclonal Antibody

  • WB - Vitronectin Antibody AJ1817b
    A. Western blot analysis on Hu Serum membrane using anti-vitronectin RabMAb (Cat. #AJ1817b), dilution 1:20,000
  • IHC - Vitronectin Antibody AJ1817b
    B. Immunohistochemical staining of paraffin-embedded human liver tissue using anti-vitronectin RabMAb (Cat. #AJ1817b).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P04004
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Monoclonal
Clone Names EP873Y
Calculated MW 54306 Da
Gene ID 7448
Other Names Vitronectin, VN, S-protein, Serum-spreading factor, V75, Vitronectin V65 subunit, Vitronectin V10 subunit, Somatomedin-B, VTN
Target/Specificity A synthetic peptide corresponding to residues near the V10 subunit of human vitronectin was used as an immunogen.
Dilution WB~~1:2000~5000
Format 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVitronectin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VTN
Function Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Cellular Location Secreted, extracellular space.
Tissue Location Plasma.
Research Areas
Citations (0)

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Vitronectin, a 75 kDa polypeptide along with a 10 kDa fragment, is a glycoprotein present on most cell surfaces, in extracellular fluids and plasma (1). Vitronectin promotes cellular adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway and binds to several serpin serine protease inhibitors (2). As a member of the integrin family, Vitronectin contains the cell binding sequence arg gly asp (RGD), first found in fibronectin, and serves as a cell-to-substrate adhesion molecule (3). Vitronectin acts as an inhibitor of the complement cascade by binding to the C5b9 complex and it has also been shown to have has a novel and direct role in self-senescent-self intercellular recognition leading to macrophage phagocytosis of cells undergoing apoptosis (4).


1. Rouslahti E, et al. J Invest Dermatol 79:65-68, 1982
2. Bauer JS, et al. J Cell Biol. 116(2):477-87, 1992
3. Stefansson S, et al. Nature 383(6599):390-1, 1996
4. Savill J, et al. Nature 343:170-3, 1990

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Cat# AJ1817b
(40 western blots)
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