|Application ||IHC-P, E|
|Dilution||IHC-P (20 µg/ml)|
|Other Names||Neuropeptides B/W receptor type 1, G-protein coupled receptor 7, NPBWR1, GPR7|
|Target/Specificity||Human NPBWR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||NPBWR1 / GPR7 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.|
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Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.
O'Dowd B.F.,et al.Genomics 28:84-91(1995).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Brezillon S.,et al.J. Biol. Chem. 278:776-783(2003).
Tanaka H.,et al.Proc. Natl. Acad. Sci. U.S.A. 100:6251-6256(2003).
Sjoeblom T.,et al.Science 314:268-274(2006).
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