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HCAR3 / GPR109B / HM74 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - HCAR3 / GPR109B / HM74 Antibody (N-Terminus) ALS10059
    Anti-GPR109B / HM74 antibody IHC of human spleen.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, ICC
Primary Accession P49019
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 44kDa
Dilution IHC-P (3-4 µg/ml)
Additional Information
Gene ID 8843
Other Names Hydroxycarboxylic acid receptor 3, G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, Niacin receptor 2, Nicotinic acid receptor 2, HCAR3, GPR109B, HCA3, HM74B, NIACR2
Target/Specificity Human GPR109B / HM74. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except HCAR2 (100%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsHCAR3 / GPR109B / HM74 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HCAR3
Synonyms GPR109B, HCA3, HM74B, NIACR2
Function Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expression largely restricted to adipose tissue and spleen.
Volume 50 µl
Research Areas
Citations (0)

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Background

Receptor for 3-OH-octanoid acid mediates a negative feedback regulation of adipocyte lipolysis to counteract prolipolytic influences under conditions of physiological or pathological increases in beta-oxidation rates. Acts as a low affinity receptor for nicotinic acid. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet.

References

Nomura H.,et al.Int. Immunol. 5:1239-1249(1993).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Scherer S.E.,et al.Nature 440:346-351(2006).
Wise A.,et al.J. Biol. Chem. 278:9869-9874(2003).

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$ 395.00
Cat# ALS10059
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