|Dilution||IHC-P (5-10 µg/ml)|
|Other Names||Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor, MTNR1A|
|Target/Specificity||Human MTNR1A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||MTNR1A / Melatonin Receptor 1a Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus|
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High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Reppert S.M.,et al.Neuron 13:1177-1185(1994).
Ebisawa T.,et al.Biochem. Biophys. Res. Commun. 262:832-837(1999).
Huang Y.-H.,et al.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
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