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CCR4 Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - CCR4 Antibody (C-Terminus) ALS10099
    Anti-CCR4 antibody IHC of human Lung, Non-Small Cell Carcinoma.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P51679
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 41kDa
Dilution IHC-P (2-3 µg/ml)
Additional Information
Gene ID 1233
Other Names C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4, CCR-4, CCR4, K5-5, CD194, CCR4, CMKBR4
Target/Specificity Human CCR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsCCR4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCR4
Synonyms CMKBR4
Function High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells
Volume 50 µl
Research Areas
Citations (0)

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Background

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.

References

Power C.A.,et al.J. Biol. Chem. 270:19495-19500(1995).
Kato H.,et al.Genes Immun. 1:97-104(1999).
Kopatz S.A.,et al.Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
Imai T.,et al.J. Biol. Chem. 272:15036-15042(1997).
Imai T.,et al.J. Biol. Chem. 273:1764-1768(1998).

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$ 395.00
Cat# ALS10099
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