|Application ||IHC-P, ICC|
|Reactivity||Human, Mouse, Hamster, Monkey, Horse, Bovine, Dog|
|Dilution||IHC-P (3.6 µg/ml)|
|Other Names||Prostaglandin E2 receptor EP4 subtype, PGE receptor EP4 subtype, PGE2 receptor EP4 subtype, Prostanoid EP4 receptor, PTGER4, PTGER2|
|Target/Specificity||Human PTGER4 / EP4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||PTGER4 / EP4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Bastien L.,et al.J. Biol. Chem. 269:11873-11877(1994).
An S.,et al.Biochem. Biophys. Res. Commun. 197:263-270(1993).
Foord S.M.,et al.Genomics 35:182-188(1996).
Mori K.,et al.J. Mol. Med. 74:333-336(1996).
Kopatz S.A.,et al.Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
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