|Dilution||IHC-P (14 µg/ml)|
|Other Names||G-protein coupled receptor 78, GPR78|
|Target/Specificity||Human GPR78. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GPR78 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||High level of expression in placenta. Expressed throughout the brain at low level. No expression detected in skeletal muscle, lung, heart, liver, pancreas, or kidney.|
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Provided below are standard protocols that you may find useful for product applications.
Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP.
Lee D.K.,et al.Gene 275:83-91(2001).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Jones P.G.,et al.Biochim. Biophys. Acta 1770:890-901(2007).
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