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GPR52 Antibody (Cytoplasmic Domain)

Rabbit Polyclonal Antibody

     
  • IHC - GPR52 Antibody (Cytoplasmic Domain) ALS10117
    Anti-GPR52 antibody ALS10117 IHC of human brain.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P, E
Primary Accession Q9Y2T5
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 41kDa
Dilution IHC-P (2.5 µg/ml)
Additional Information
Gene ID 9293
Other Names Probable G-protein coupled receptor 52, GPR52
Target/Specificity Human GPR52. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsGPR52 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR52 {ECO:0000303|PubMed:9931487, ECO:0000312|HGNC:HGNC:4508}
Function Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed in brain, especially in striatum.
Volume 50 µl
Research Areas
Citations (0)

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Background

Orphan receptor.

References

Sawzdargo M.,et al.Brain Res. Mol. Brain Res. 64:193-198(1999).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 425.00
Cat# ALS10117
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