|Dilution||IHC-P (7-14 µg/ml)|
|Other Names||Glucose-dependent insulinotropic receptor, G-protein coupled receptor 119, GPR119|
|Target/Specificity||Human GPR119. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||GPR119 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Predominantly expressed in the pancreas, especially in the islets.|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Takeda S.,et al.FEBS Lett. 520:97-101(2002).
Suwa M.,et al.Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
Fredriksson R.,et al.FEBS Lett. 554:381-388(2003).
Ross M.T.,et al.Nature 434:325-337(2005).
Soga T.,et al.Biochem. Biophys. Res. Commun. 326:744-751(2005).
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