|Dilution||IHC-P (5-10 µg/ml)|
|Other Names||5-hydroxytryptamine receptor 4, 5-HT-4, 5-HT4, Serotonin receptor 4, HTR4|
|Target/Specificity||Human 5HT4 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||HTR4 / 5-HT4 Receptor Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.|
|Tissue Location||Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle|
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Provided below are standard protocols that you may find useful for product applications.
This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Blondel O.,et al.J. Neurochem. 70:2252-2261(1998).
Van den Wyngaert I.,et al.Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
Claeysen S.,et al.NeuroReport 8:3189-3195(1997).
Syversveen T.,et al.Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
Claeysen S.,et al.Mol. Pharmacol. 55:910-920(1999).
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