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ADRA1B Antibody (C-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - ADRA1B Antibody (C-Terminus) ALS10147
    Anti-ADRA1B antibody ALS10147 IHC of human adrenal, medulla.
  • SPECIFICATION
  • CITATIONS
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  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession P35368
Reactivity Human, Mouse, Hamster, Monkey, Bovine, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 57kDa
Dilution IHC-P (11 µg/ml)
Additional Information
Gene ID 147
Other Names Alpha-1B adrenergic receptor, Alpha-1B adrenoreceptor, Alpha-1B adrenoceptor, ADRA1B
Target/Specificity Human ADRA1B. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PLEKHG5 (45%).
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsADRA1B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ADRA1B
Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Cellular Location Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes
Volume 50 µl
Research Areas
Citations (0)

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Background

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

References

Ramarao C.S.,et al.J. Biol. Chem. 267:21936-21945(1992).
Forray C.,et al.Mol. Pharmacol. 45:703-708(1994).
Schwinn D.A.,et al.J. Pharmacol. Exp. Ther. 272:134-142(1995).
Wright C.D.,et al.Circ. Res. 103:992-1000(2008).
Wright C.D.,et al.Cell. Signal. 24:794-802(2012).

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$ 395.00
Cat# ALS10147
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