|Reactivity||Human, Mouse, Hamster, Monkey, Bovine, Dog|
|Dilution||IHC-P (11 µg/ml)|
|Other Names||Alpha-1B adrenergic receptor, Alpha-1B adrenoreceptor, Alpha-1B adrenoceptor, ADRA1B|
|Target/Specificity||Human ADRA1B. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PLEKHG5 (45%).|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||ADRA1B Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.|
|Cellular Location||Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes|
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Provided below are standard protocols that you may find useful for product applications.
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
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Forray C.,et al.Mol. Pharmacol. 45:703-708(1994).
Schwinn D.A.,et al.J. Pharmacol. Exp. Ther. 272:134-142(1995).
Wright C.D.,et al.Circ. Res. 103:992-1000(2008).
Wright C.D.,et al.Cell. Signal. 24:794-802(2012).
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