|Reactivity||Human, Rabbit, Pig, Horse, Dog|
|Dilution||IHC-P (10 µg/ml)|
|Other Names||High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8A, 188.8.131.52, PDE8A|
|Target/Specificity||Human PDE8A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.|
|Reconstitution & Storage||Long term: -70°C; Short term: +4°C|
|Precautions||PDE8A Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.|
|Tissue Location||Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon|
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Provided below are standard protocols that you may find useful for product applications.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.
Wang P.,et al.Gene 280:183-194(2001).
Glavas N.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:6319-6324(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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