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PDE8A Antibody (N-Terminus)

Rabbit Polyclonal Antibody

     
  • IHC - PDE8A Antibody (N-Terminus) ALS10153
    Anti-PDE8A antibody ALS10153 IHC of human prostate.
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession O60658
Reactivity Human, Rabbit, Pig, Horse, Dog
Host Rabbit
Clonality Polyclonal
Calculated MW 93kDa
Dilution IHC-P (10 µg/ml)
Additional Information
Gene ID 5151
Other Names High affinity cAMP-specific and IBMX-insensitive 3', 5'-cyclic phosphodiesterase 8A, 3.1.4.53, PDE8A
Target/Specificity Human PDE8A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Long term: -70°C; Short term: +4°C
PrecautionsPDE8A Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDE8A
Function Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory- phosphorylation and stimulates RAF1-dependent EGF-activated ERK- signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).
Tissue Location Expressed in most tissues except thymus and peripheral blood leukocytes. Highest levels in testis, ovary, small intestine and colon
Volume 50 µl
Research Areas
Citations (0)
citation

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Background

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development.

References

Wang P.,et al.Gene 280:183-194(2001).
Glavas N.A.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:6319-6324(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

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$ 467.50
Cat# ALS10153
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